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Cover art for S.E.M.I.: Side Effects May Include...

Available Digital · physical unverified

Released
Jan 23, 2026
Studio
Two Horn Unicorn
Platforms
1

S.E.M.I.: Side Effects May Include...

Jan 23, 2026 Two Horn Unicorn 1 platform

Arcade Beat 'em up Indie Action Comedy Party

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.

Track the collection you actually own — yourself, or with your AI assistant.

Free, no card, and your collection stays yours to export.

Free, no card, yours to export.

Released
  • November 20, 2025Worldwide
  • January 23, 2026
Also known as
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Versions
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Standalone expansions
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Languages
9 languages Brazilian Portuguese, Dutch, English, French, Japanese, Russian, Simplified Chinese, Spanish fully voiced
  • Brazilian Portuguese audio · interface
  • Dutch audio · interface
  • English audio · interface
  • French audio · interface
  • German interface
  • Japanese audio · interface
  • Russian audio · interface
  • Simplified Chinese audio · interface
  • Spanish audio · interface

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